Opportunities are available in the lab to study mechanisms of noncoding RNA function in stem cell maintenance, differentiation and reprogramming. Stem cells are multipotential cells, which are able to indefinitely self-renew, while maintaining the ability to differentiate into the myriad cell types which constitute a multicellular mammalian organism. Often, cells that drive tumorigenesis, tumor evolution, and resistance to therapies display stem cell characteristics. Over the long term, our goals are based on bridging the gap between normal stem cell functions in development and tissue homeostasis, and cancer stem cell contributions to tumors.
Personnel
Serena Wooten
Clemencio Salvador
Della Yee
Past Members
Sarah Miller (now at McKinsey & Company)
Collaborators
Mauro Calabrese (UNC, Pharmacology)
Praveen Sethupathy (Cornell University)
Jesse Raab (UNC, Genetics)
Jeremy Simon (UNC, Neuroscience)
Joshua Starmer (UNC, Genetics)